Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 9;10:21492. doi: 10.1038/s41598-020-76338-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Immunohistochemistry of mdx TA muscles treated with S56 PMO showed higher sarcolemmal expression of utrophin. (a) TA muscles were stained with α-bungarotoxin (green), utrophin antibody (red) and wheat germ agglutinin (cyan). The control PMO and S56 PMO treated cryosections were also stained with utrophin pre-immune sera as control. Scale bar = 100 µm. The figures showed synaptic expression of utrophin in control PMO, and both synaptic and extra-synaptic sarcolemma associated expression of utrophin in S56 PMO treated mice. (b) Quantification of utrophin expression in sarcolemma normalized with WGA expression. S56 PMO treated muscles showed significantly higher expression of utrophin (****p = 0.0001, n = 4 mice for both groups). Statistical analysis performed by Mann–Whitney nonparametric test.