Fig. 1.

Circulating cytokine concentrations. Concentrations of circulating a tumor necrosis factor (TNF)-α, b interleukin (IL)-6, c IL-8, d IL-10, e interferon gamma-induced protein (IP)-10, f monocyte chemoattractant protein (MCP)-1, and g IL-1 receptor antagonist (IL-1RA) on day of intensive care unit (ICU) admission and serial data within six days pre- and post-alignment day (day 0). Data are presented as geometric mean with 95% confidence intervals and were analyzed using mixed-models analysis (time*group interaction factor) to evaluate differences between groups over time. p values under graph titles reflect overall between-group differences (day − 6 until day 6). Between-group p values for day − 6 until day 0 and day 0 until day 6 are shown on the left and right of each panel, respectively