Table 3. Final Diagnosis, In-Hospital, and 12-Month Clinical Events by Randomized Arm.
| Factor | Control | Intervention | Odds ratio (95% CI) | P valuea |
|---|---|---|---|---|
| No. | 1183 | 1135 | NA | NA |
| Final diagnosis | ||||
| NSTEMI | 323 (27.3) | 373 (32.9) | NA | .18 |
| STEMI | 649 (54.9) | 634 (55.9) | NA | |
| Unstable angina | 211 (17.8) | 128 (11.3) | NA | |
| In-hospital events | ||||
| In-hospital death | 22 (1.9) | 19 (1.7) | 0.95 (0.38-2.38) | .92 |
| New/recurrent MI | 24 (2.0) | 13 (1.1) | 0.54 (0.21-1.29) | .20 |
| Recurrent ischemia | 94 (7.9) | 18 (1.6) | 0.21 (0.07-0.68) | .009 |
| Cardiac arrest | 20 (1.7) | 34 (3.0) | 1.87 (0.87-4.04) | .10 |
| Congestive heart failure | 89 (7.5) | 101 (8.9) | 1.35 (0.66-2.76) | .41 |
| Ventricular arrhythmia | 14 (1.2) | 15 (1.3) | 1.16 (0.49-2.78) | .73 |
| Stroke/TIA | 7 (0.6) | 3 (0.3) | 0.49 (0.15-1.55) | .22 |
| TIMI major bleeding | 69 (5.8) | 70 (6.2) | 1.08 (0.64-1.81) | .76 |
| Events by 12 mo | ||||
| No. | 1087 | 1044 | NA | NA |
| Death | 87 (8.0) | 54 (5.2) | 0.60 (0.31-1.15) | .12 |
| MI | 73 (6.7) | 49 (4.7) | 0.73 (0.48-1.12) | .15 |
| Heart failure | 115 (10.6) | 120 (11.5) | 1.16 (0.58-2.30) | .68 |
| CVA | 9 (0.8) | 5 (0.5) | 0.60 (0.27-1.35) | .22 |
| Death or MI | 146 (13.4) | 96 (9.2) | 0.66 (0.38-1.14) | .13 |
| Death/MI/stent thrombosis | 149 (13.7) | 97 (9.3) | 0.65 (0.37-1.13) | .13 |
| Events by 12 mo (high-risk cohort) | ||||
| No. | 639 | 668 | ||
| Death | 56 (8.8) | 30 (4.5) | 0.44 (0.21-0.91) | .03 |
| MI | 50 (7.8) | 43 (6.4) | 0.88 (0.51-1.52) | .64 |
| Heart failure | 87 (13.6) | 105 (15.7) | 1.10 (0.54-2.27) | .79 |
| CVA | 5 (0.8) | 4 (0.6) | 1.10 (0.37-3.33) | .86 |
| Death or MI | 96 (15.0) | 66 (9.9) | 0.60 (0.32-1.14) | .12 |
| Death/MI/stent thrombosis | 98 (15.3) | 67 (10.0) | 0.60 (0.32-1.13) | .12 |
Abbreviations: CVA, cerebrovascular accident; MI, myocardial infarction; NA, not applicable; NSTEMI, non–ST-segment elevation myocardial infarction; STEMI, ST-segment elevation myocardial infarction; TIA, transient ischemic attack; TIMI, thrombolysis in myocardial infarction.
a
P values adjusted for clustered design.