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. 2020 Nov 24;5(48):30937–30945. doi: 10.1021/acsomega.0c03707

Figure 3.

Figure 3

Effects of valine supplementation on glucose and insulin tolerance in mice. Glucose tolerance test (GTT) and insulin tolerance test (ITT) were performed at the 11th and 12th weeks of valine intervention. Before the GTT and ITT tests, the mice were fasted for 16 or 9 h, respectively. Glucose and insulin were intraperitoneally injected with a final concentration of 2 g/kg or 0.75 U/kg body weight. (A) Glucose tolerance test (GTT) and (B) corresponding area under curve (AUC). (C) Insulin tolerance test (ITT), and (D) corresponding AUC (n = 8/group). Values are means ± SEM (n = 8), and columns accompanied by the same letter are not significantly different from each other. Abbreviations: chow diet + water (CW); chow diet + valine (CV); high-fat diet + water (HW); and high-fat diet + valine (HV).