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. 2020 Dec 3;12:12509–12517. doi: 10.2147/CMAR.S280554

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© 2020 Gao et al.

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Alox12-12-HETE axis is required for CML cell growth and survival. (A) ALOX12 knockdown decreases Alox12 and 12-HETE level in K562 cells. (B) Proliferation is decreased and (C) apoptosis is increased in ALOX12- depleted K562 cells, and the effects are reversed by the addition of 12-HETE (1 μM). Cells are electroporated with 100 nM scramble or ALOX12 siRNA and cultured for 24 hours prior to assays. ML355 (10 μM) significantly decreases 12-HETE level (D), inhibits proliferation (E) and induces apoptosis (F) of K562 cells. Proliferation and apoptosis were determined after 72 hours drug treatment. *p<0.05, compared to scramble siRNA or DMSO.