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. 2020 Dec 3;12:12509–12517. doi: 10.2147/CMAR.S280554

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© 2020 Gao et al.

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Alox12 inhibition selectively targets BP-CML CD34 stem/progenitor cells, and acts synergistically with dasatinib. Combination of ML355 and dasatinib selectively induces apoptosis (A), inhibits colony formation (B) and self-renewal capacity (C and D) in CML CD34 cells (n=10) without affecting NBM CD34 cells (n=5). Colonies were enumerated and individually picked for serial replating. Graphs presented are mean of the results obtained from ten BP-CML patients and five NBM. *p<0.5, compared to control or dasatinib alone.