TABLE 3.
Comparison of characteristics for PI*ZZ and PI*MM genotypes among individuals with COPD
| ZZ | MM | p-value | |
| Subjects | 31 (0.17) | 15 502 (95) | |
| Age years | 56 (49–63) | 62 (57–66) | 0.47 |
| Male | 21 (68) | 8016 (52) | 0.1 |
| Height cm | 173.5±9.9 | 167.8±9.2 | 1.5×10−3 |
| No height information | 0 | 63 (0.41) | 1 |
| BMI kg·m−2 | 25.8±4.9 | 28.4±5.7 | 1.9×10−3 |
| No BMI information | 0 | 100 (0.65) | 1 |
| Respiratory symptoms | 28 (90) | 11 470 (74) | 0.04 |
| AATD diagnosis | 7 (23) | 2 (0.013) | 2.3×10−18 |
| Exposure to smoke or polluted air | 10 (32) | 4173 (27) | 0.54 |
| Smoking status | 30 (97) | 15 159 (98) | 0.51 |
| Current smokers# | 2 (6.7) | 4328 (29) | 7.1×10−3 |
| Ex-smokers# | 19 (63) | 7249 (48) | 0.10 |
| Never-smokers# | 9 (30) | 3582 (24) | 4.7×10−3 |
| PFT | 14 (45) | 9427 (61) | 0.095 |
| FEV1 L | 1.5 (1.7–2.7) | 2.2 (1.7–2.7) | 0.073 |
| FEV1/FVC | 0.48 (0.42–0.65) | 0.70 (0.62–0.76) | 4.1×10−5 |
| FEV1 % predicted | 45 (36–79) | 76 (62–90) | 3.8×10−3 |
Data are presented as n (%), median (interquartile range) or mean±sd, unless otherwise stated. n=17 790. BMI: body mass index; AATD: alpha-1 antitrypsin deficiency; PFT: pulmonary function testing; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity. #: percentage was calculated among subjects with information on smoking status.