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. 2020 Dec 9;18:467. doi: 10.1186/s12967-020-02643-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — DNA methylation levels of chr6:108882977 (FOXO3) and chr17:7591672 (TP53) and their accuracy in predicting LOA. a, b The methylation levels of chr6:108882977 (FOXO3) and chr17:7591672 (TP53) in the peripheral blood of HCs < 60 years old and ≥ 60 years old. c, d The methylation levels of chr6:108882977 (FOXO3) and chr17:7591672 (TP53) in peripheral blood of LOA patients and HCs. e ROC curve of DMS (chr6:108882977) and age. f ROC curve of DMS (chr17:7591672) and age. g ROC curve of the two DMSs and age. (H) A PCA plot consisting of the two DMSs and age. *p < 0.05; **p < 0.01; **p < 0.001