Fig. 6.

Sensitivity analysis of PCSK9 on a continuous scale and risk for incident type 2 diabetes in female subjects who met at least two of the three glycemic criteria for prediabetes (a) and the relationship between PCSK9 and confirmed type 2 diabetes in female subjects (b). Hazard ratios (HRs) are represented by solid lines and 95% CIs by shaded areas. The reference standard was a median PCSK9 level. The model was adjusted for age, smoking, drinking, physical activity, educational attainment, BMI, waist circumference, TGs, LDL-C, SBP, ALT, AST, GGT, CRP, and HOMA-IR; p values < 0.001 for the overall association and > 0.1 for nonlinearity for all outcomes