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. 2020 Dec 9;20:593. doi: 10.1186/s12935-020-01694-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — MiR-4500 exerted its anti-cancer effects in BC cells by targeting IGF1. BT549 and HCC38 cells were transfected with miR-NC, miR-4500, miR-4500 + pcDNA3.0-NC, or miR-4500 + pcDNA3.0-IGF1. a Cell viability was assessed by CCK-8 assay. b Flow cytometry was applied to analyze the cell cycle distribution. c, d Western blot assay was performed to measure the protein levels of CDK4 and CDK6. e, f Transwell assay was employed to determine cell migration and invasion. ***P < 0.001