Table 3.

Diagnostic accuracy of WBCC and CRP for anastomotic leakage after transthoracic esophageal resection

WBCC	POD	AUC	Cut-off [/nl]	Sensitivity	Specificity	NPV	PPV	Accuracy	p value
	0	n/a	n/a	n/a	n/a	n/a	n/a	n/a	0.984
	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	0.337
	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	0.121
	3	0.65	11	44%	76%	82.1%	35.1%	0.71	0.005*
	4	0.67	8	64%	58%	84.6%	31.3%	0.62	0.0005*
	5	0.55	8	65%	53%	83.5%	28.9%	0.58	0.021*
	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	0.075
	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	0.246

CRP	POD	AUC	Cut-off [mg/l]	Sensitivity	Specificity	NPV	PPV	Accuracy	p value
	0	n/a	n/a	n/a	n/a	n/a	n/a	n/a	0.529
	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	0.363
	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	0.075
	3	0.6	150	72%	44%	84.3%	27.6%	0.52	0.014*
	4	0.65	145	68%	63%	86.9%	35.1%	0.91	0.0001*
	5	0.6	155	46%	71%	81.6%	31.7%	0.69	0.0001*
	6	0.53	120	64%	50%	82.4%	27.4%	0.57	0.0004*
	7	0.52	140	57%	51%	80%	25.5%	0.58	0.002*

WBCC: white blood cell count; CRP: C-reactive protein; NUn: Noble and Underwood; POD: postoperative day; AUC: Area under the curve; NPV: negative predictive value; PPV: positive predictive value; n/a: not available

* p ≤ 0.05