Table 1.

Discriminative Ability of Each eGFR Method, Biomarker, and Regression Models, for Cardiovascular Death and Major Bleeding

	Cardiovascular Death		Major Bleeding
	C Index	95% CI	C Index	95% CI
eGFR method
Cockcroft‐Gault	0.608	0.582–0.634	0.612	0.589–0.635
MDRD	0.575	0.550–0.600	0.575	0.551–0.600
CKD‐EPICreatinine	0.579	0.553–0.605	0.592	0.568–0.616
CKD‐EPICysC	0.628	0.603–0.653	0.611	0.588–0.634
CKD‐EPICysC+Creatinine	0.615	0.590–0.640	0.612	0.589–0.636
Biomarkers
Creatinine	0.584	0.558–0.611	0.582	0.558–0.605
CysC	0.631	0.606–0.656	0.608	0.585–0.631
Creatinine+CysC	0.637	0.612–0.661	0.619	0.597–0.642
Regression model
Age+sex+weight	0.618	0.593–0.642	0.627	0.605–0.648
Regression model and biomarkers
Age+sex+weight+creatinine	0.633	0.609–0.658	0.645	0.623–0.667
Age+sex+weight+CysC	0.667	0.643–0.692	0.649	0.627–0.671
Age+sex+weight+creatinine+CysC	0.673	0.649–0.696	0.656	0.634–0.678
Regression model and eGFR
Age+sex+weight+Cockcroft‐Gault	0.638	0.614–0.662	0.640	0.618–0.662
Age+sex+weight+MDRD	0.633	0.609–0.658	0.642	0.620–0.664
Age+sex+weight+CKD‐EPICreatinine	0.637	0.613–0.662	0.642	0.621–0.664
Age+sex+weight+CKD‐EPICysC	0.666	0.642–0.690	0.648	0.626–0.670
Age+sex+weight+CKD‐EPICysC+Creatinine	0.657	0.632–0.681	0.650	0.628–0.672

CKD‐EPI indicates Chronic Kidney Disease Epidemiology Collaboration; CysC, Cystatin C; eGFR, estimated glomerular filtration rate; and MDRD, Modification of Diet in Renal Disease.