Table 3.
Comparison of Cardiac Markers, Laboratory Findings, and Blood Gas Analysis of Patients With COVID‐19
| Normal Range | ACI group (n=9) | Cardiac Marker Abnormalities Group (n=46) | Without Cardiac Marker Abnormalities Group (n=47) | P Value | |
|---|---|---|---|---|---|
| Laboratory findings | |||||
| CRP, mg/mL | 0–5 | 60.3 (25.4–115.6) | 14.2 (4.5–38.0)* | 3.1 (1.3–9.8) * | <0.001 |
| d‐dimer, μg/mL | 0–1 | 1.8 (1.2–4.9) | 0.8 (0.7–1.1)* | 0.6 (0.5–0.7) * | <0.001 |
| Procalcitonin, ng/mL | 0–0.5 | 0.08 (0.04–0.6) | 0.03 (0.02–0.06)* | 0.2 (0.19–0.29) * | <0.001 |
| Blood routine test | |||||
| White blood count, ×109/L | 3.5–9.5 | 5.7 (2.7–7.7) | 5.5 (4.0–7.9) | 5.4 (4.2–6.8) | 0.847 |
| Neutrophil, ×109/L | 2.0–7.0 | 5.3 (2.0–5.6) | 3.6 (2.6–5.4) | 3.5 (2.4–4.6) | 0.365 |
| Lymphocyte count, ×109/L | 0.8–4.0 | 0.5 (0.4–1.1) | 1.0 (0.6–1.3)* | 1.4 (0.9–1.8) * | <0.001 |
| Red cell count, ×109/L | 3.5–5.5 | 3.4 (2.6–3.6) | 4.5 (4.0–4.9)* | 4.6 (4.1–5.0)* | <0.001 |
| Hemoglobin, g/L | 110–160 | 90.0 (66.0–113.5) | 131.0 (122.5–143.5)* | 134.0 (123.0–148.0)* | <0.001 |
| Platelet count, ×109/L | 100–300 | 115.0 (96.5–139.5) | 164.0 (119.5–222.0)* | 183.0 (147.0–232.0)* | 0.011 |
| Blood gas analysis | |||||
| pH | 7.35–7.45 | 7.40 (7.34,7.42) | 7.41 (7.38,7.43) | 7.38 (7.35,7.39)† | <0.001 |
| Lactate, mmol/L | 0.5–1.6 | 1.8 (1.6–2.0) | 2.0 (1.7–2.4) | 2.3 (1.7–2.7)† | 0.136 |
| PaCO2, mm Hg | 35–45 | 34.7 (30.3–40.8) | 39.7 (36.7–42.1) | 41.6 (38.9–44.9) * | 0.001 |
| PaO2, mm Hg | 90–110 | 77.4 (65.4–101.5) | 89.9 (77.3–100.7) | 87.5 (77.5–103.2) | 0.333 |
| Cardiac markers | |||||
| LDH, U/L | 109–245 | 289.0 (227.5–429.5) | 248.0 (219.3–288.5)* | 191.0 (158.0–213.0) * | <0.001 |
| HBDH, U/L | 72–182 | 235.0 (183.0–334.0) | 192.0 (158.0–222.0)* | 143.0 (122.5–156.5) * | <0.001 |
| CK, U/L | 25–196 | 139.0 (58.5–259.0) | 74.0 (48.5–198.0) | 61.0 (46.5–94.0) * | 0.014 |
| Myoglobin, ng/mL | 28–72 | 149.0 (107.3–706.7) | 31.0 (21.0–47.4)* | 21.0 (21.0–20.8) * | <0.001 |
| TNT‐HSST, pg/mL | 0–14 | 69.5 (34.9–145.1) | 7.4 (5.3–9.4)* | 4.4 (3.0–6.7) * | <0.001 |
| NT‐proBNP, pg/mL | 0–85.8 | 2798.0 (442.2–10 226.0) | 97.8 (38.0–229.7)* | 28.3 (14.8–43.5) * | <0.001 |
ACI indicates acute cardiac injury; CK, creatine kinase; CRP, C‐reactive protein; HDBH, hydroxybutyrate dehydrogenase; LDH, lactate dehydrogenase; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide; PaCO2, partial pressure of carbon dioxide; PaO2, partial pressure of oxygen; and TNT‐HSST, troponin T hypersensitivity.
a
Mean P<0.05 compared with the ACI group.
b
P<0.05 compared with the group with cardiac marker abnormalities.