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. 2020 Sep 1;9(18):e017404. doi: 10.1161/JAHA.120.017404

Figure 3. Purinergic receptor as the potential therapeutic target for the treatment of pulmonary hypertension.

Figure 3

In pulmonary hypertension, A2B, P2X7, P2Y1, P2Y11, and P2Y12 receptors are upregulated (red) and A2A receptors are downregulated (white) in the pulmonary vasculature. The potential receptors (A2A, A2B, and P2X7) as therapeutic targets are highlighted with the capsule symbols, whereas the A2AR may be involved in initiation of the disease (generated by Biorender).