Table 1.
Baseline demographics for the study cohort.
| Demographic | All(n = 56) | PPMS(n = 32) | SPMS(n = 24) | PPMS vs. SPMS (significance, p) |
|---|---|---|---|---|
| Male/Female | 26/30 | 22/10 | 4/20 | 0.0001 |
| Age, years | 53.6 (8.0) | 53.88 (9.98) | 53.13 (4.48) | 0.362 |
| Disease duration, years | 12.2 (8.60) | 8.82 (8.0) | 16.8 (7.20) | <0.0001 |
| BMI | 27.9 (5.90) | 28.06 (5.09) | 27.74 (6.94) | 0.696 |
| EDSS | 5.7 (1.30) | 5.42 (1.54) | 6.0 (0.84) | 0.352 |
| MSFC score | –0.017 (0.75) | –0.06 (0.71) | –0.11 (0.80) | 0.540 |
| T25FW, seconds | 13.8 (11.10) | 12.36 (9.54) | 15.79 (12.82) | 0.034 |
| 9-HPT, seconds | 34.6 (50.50) | 39.21 (66.50) | 28.39 (7.80) | 0.889 |
| PASAT | 43.2 (12.60) | 43.75 (13.15) | 42.38 (12.02) | 0.551 |
| MSIS-phys | 49.0 (13.10) | 47.66 (13.90) | 50.75 (12.11) | 0.422 |
| MSIS-psych | 18.0 (6.10) | 16.31 (5.88) | 20.17 (5.85) | 0.019 |
| Fatigue score | 15.50 (6.30) | 14.28 (6.63) | 17.13 (5.60) | 0.103 |
| BDI | 5.20 (4.70) | 4.52 (4.60) | 6.17 (4.79) | 0.180 |
| EA, joules | 1401.8 (1510.6) | 1460.79 (1783.87) | 1323.13 (1075.34) | 0.954 |
| METs | 1.30 (0.30) | 1.29 (0.26) | 1.28 (0.26) | 0.997 |
| PhAD, hours | 1.20 (1.20) | 1.19 (1.32) | 1.28 (1.14) | 0.663 |
| Step count | 3411.50 (2913.6) | 3607.31 (3330.32) | 3150.43 (2286.05) | 0.85 |
| RAM score | 0.007 (0.50) | –0.01 (0.62) | 0.03 (0.42) | 0.889 |
Note: Values represent mean (SD). The differences between PPMS and SPMS baseline scores were determined using a Mann-Whitney U test.