Table 4.
Responsiveness over the 30 month follow-up period for all participants.
| Disability measure |
Baseline median (IQR) |
End median (IQR) |
Significance |
Effect size |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
(exact, 2-tailed) | ||||||||||||
| All | PPMS | SPMS | All | PPMS | SPMS | All | PPMS | SPMS | All | PPMS | SPMS | |
| EDSS | 6.0 (0.5) | 6.0 (1.75) | 6.0(0.5) | 6.5 (0.5) | 6.5 (0.5) | 6.5 (0.5) | 0.0005 | 0.004 | 0.092 | 0.49 | 0.53 | 0.45 |
| MSFC score | 0.06 (1.1) | 0.07 (1.09) | 0.04 (1.2) | 0.05 (1.27) | 0.04 (1.72) | 0.14 (1.13) | 0.0003 | 0.001 | 0.111 | 0.51 | 0.6 | 0.35 |
| T25FW, seconds | 9.95 (7.61) | 8.82 (5.79) | 11.66 (6.48) | 11.99 (10.71) | 12.46 (13.66) | 11.99 (7.92) | 0.0002 | <0.0001 | 0.393 | 0.51 | 0.77 | 0.19 |
| 9-HPT, seconds | 26.92 (9.63) | 26.15 (10.68) | 27.44 (9.14) | 25.68 (12.13) | 27.46 (16.25) | 24.02 (8.75) | 0.067 | 0.014 | 0.919 | 0.26 | 0.46 | 0.03 |
| PASAT | 46.5 (21.75) | 49.0 (21.75) | 44.5 (21.75) | 46.0 (24.0) | 47.0 (30.25) | 46.0 (15.5) | 0.035 | 0.023 | 0.821 | 0.3 | 0.43 | 0.05 |
| MSIS-phys | 50.0 (20.5) | 48.0 (20.75) | 50.5 (19.0) | 49.0 (17.0) | 48.5 (26.25) | 50.0 (15) | 0.336 | 0.383 | 0.693 | 0.14 | 0.17 | 0.09 |
| MSIS-psych | 16.5 (9.75) | 15.5 (6.75) | 20.5 (11.25) | 19.0 (10.0) | 16.0 (10.75) | 21.0 (11.0) | 0.332 | 0.17 | 0.908 | 0.14 | 0.26 | 0.03 |
| Fatigue score | 14.0 (8.75) | 13.0 (7.5) | 16.5 (9.25) | 16.0 (8.5) | 15.0 (11.0) | 18.0 (6.0) | 0.033 | 0.032 | 0.499 | 0.3 | 0.4 | 0.15 |
| BDI | 3.0 (7.0) | 3.0 (5.0) | 5.0 (9.75) | 5.0 (7.5) | 5.0 (7.0) | 4.0 (9.0) | 0.854 | 0.244 | 0.372 | 0.03 | 0.22 | 0.2 |
| EA, joules | 1169.72 (1454.91) | 1117.92 (1406.36) | 1389.78 (1691.41) | 881.31 (1321.33) | 951.2 (1384.5) | 837.78 (1343.38) | 0.078 | 0.014 | 0.927 | 0.25 | 0.46 | 0.03 |
| METs | 1.29 (0.32) | 1.25 (0.26) | 1.31 (0.42) | 1.22 (0.42) | 1.22 (0.37) | 1.23 (0.57) | 0.001 | 0.001 | 0.258 | 0.45 | 0.58 | 0.26 |
| PhAD, hours | 0.93 (1.41) | 0.9 (1.23) | 0.99 (2.06) | 0.73 (1.29) | 0.72 (1.13) | 0.73 (1.66) | 0.044 | 0.009 | 0.985 | 0.29 | 0.49 | 0.01 |
| Step count | 2503.4 (3137.42) | 2897.99 (3372.76) | 2365.16 (2965.13) | 1841.9 (2205.04) | 1881.8 (2547.62) | 1671.32 (2076) | 0.0002 | 0.001 | 0.097 | 0.52 | 0.61 | 0.38 |
| RAM score | 0.18 (0.81) | 0.18 (0.88) | 0.17 (0.81) | –0.07 (0.75) | –0.03 (0.84) | –0.15 (0.69) | 0.02 | 0.003 | 0.784 | 0.33 | 0.54 | 0.07 |
Note: Wilcoxon signed rank tests were used to assess if a significant change had occurred. Significant changes are in bold. Effect sizes were calculated by dividing the Wilcoxon Z by the square root of the number of observations (Z/√n).