Table 3.
Comparison of comorbidities between psoriatic arthritis, rheumatoid arthritis and diabetes mellitus patients.
| Comorbidity | PsA n = 215 |
RA n = 215 |
DM n = 215 |
PsA versus RA | PsA versus DM | ||
|---|---|---|---|---|---|---|---|
| Crude OR (95% CI) | Adjusted OR (95% CI) | Crude OR (95% CI) | Adjusted OR (95% CI) | ||||
| Smoking | 76 (35.4) | 62 (28.8) | 85 (39.5) | 1.35 (0.90–2.03) | 0.84 (0.57–1.24) | ||
| Hyperlipidaemia | 101 (47.0) | 67 (31.2) | 101 (47.0) | 1.96 (1.32–2.90) | – | 1 | – |
| Hypertension | 62 (28.8) | 51 (23.8) | 97 (45.1) | 1.30 (0.84–1.99) | – | 0.49 (0.33–0.74) | – |
| Obesity | 50 (29.4) | 24 (12.8) | 79 (36.7) | 2.83 (1.65–4.86) | 0.72 (0.47–1.10) | ||
| Coronary disease | 10 (4.7) | 10 (4.7) | 16 (7.4) | 1 (0.41–2.45) | 1.05 (0.31–3.57)a | 0.61 (0.27–1.37) | 0.66 (0.23–1.91)a |
| Stroke | 8 (3.7) | 2 (0.9) | 7 (3.3) | 4.12 (0.86–19.6) | 5.06 (0.80–32.1)a | 1.15 (0.41–3.22) | 1.20 (0.35–4.12)a |
| MACEs | 12 (5.6) | 12 (5.6) | 22 (10.2) | 1 (0.44–2.28) | 1.20 (0.40–3.63)a | 0.52 (0.25–1.08) | 0.42 (0.16–1.10)a |
| Osteoporosis | 12 (5.6) | 24 (11.2) | 2 (0.9) | 0.46 (0.21–1.03) | 0.67 (0.28–1.64)b | 6.22 (1.33–29.2)b | – |
| Depressionc | 42 (19.5) | 15 (7.0) | 12 (5.6) | 3.24 (1.74–6.04) | 3.02 (1.57–5.81)d | 4.11 (2.10–8.05) | 4.85 (2.37–9.93)d |
| Malignancy | 12 (5.6) | 7 (3.3) | – | 1.76 (0.68–4.55) | 1.60 (0.60–4.26)e | – | – |
Adjusted for age, sex, smoking, hypertension, hyperlipidaemia, body mass index, glucocorticoids use.
Adjusted for glucocorticoids treatment; none of the DM patients was receiving steroids.
6/42 (14.3%) PsA patients were already on antidepressants (mean ± SD time: 16.8 ± 10.9 months) at the time of PsA diagnosis (in five out of six, anti-depressants started after the diagnosis of psoriasis). The respective figure for RA was 2/15 (13.3%).
Adjusted for age, sex, disease duration, smoking.
Adjusted for age, disease duration.
CI, confidence interval; DM, diabetes mellitus; MACE, major adverse cardiovascular event; OR, odds ratio; PsA, psoriatic arthritis; RA, rheumatoid arthritis.