. 2020 Dec 8;12:1759720X20975907. doi: 10.1177/1759720X20975907

Table 2.

Testing of the diagnostic value of myositis antibodies.

MSA/MAA	n, negative tested	n, positive tested	IIM				_posLR	_negLR	ILD				_posLR	_negLR
MSA/MAA	n, negative tested	n, positive tested	Clinical sensitivity	Clinical specificity	PPV	NPV			Clinical sensitivity	Clinical specificity	PPV	NPV	_posLR	_negLR
Jo-1	1098	20	12.86	98.99	45.00	94.63	12.69	0.88	23.81	98.64	25.00	98.55	17.49	0.77
TIF1γ	1099	19	2.86	98.43	10.53	94.02	1.83	0.99	0.00	98.28	0.00	98.10	0.00	1.02
MDA-5	1103	15	4.29	98.90	20.00	94.13	3.88	0.97	9.52	98.82	13.33	98.29	8.07	0.92
NXP-2	1106	12	5.71	99.26	33.33	94.23	7.76	0.95	9.52	99.09	16.67	98.29	10.50	0.91
SAE	1114	4	2.86	99.82	50.00	94.10	15.51	0.97	4.76	99.73	25.00	98.21	17.49	0.95
PM-Scl100	1092	26	7.14	98.07	19.23	94.25	3.69	0.95	4.76	97.73	3.85	98.18	2.10	0.97
PM-Scl75	1052	66	4.29	94.20	4.55	93.85	0.74	1.02	19.05	94.37	6.06	98.39	3.39	0.86
PL-7	1094	24	8.57	98.34	25.00	94.35	5.17	0.93	28.57	98.37	25.00	98.64	17.49	0.73
EJ	1117	1	0.00	99.91	0.00	93.94	0.00	1.00	0.00	99.91	0.00	98.13	0.00	1.00
OJ	1115	3	0.00	99.72	0.00	93.93	0.00	1.00	0.00	99.73	0.00	98.13	0.00	1.00
PL-12	1091	27	1.43	97.61	3.70	93.89	0.60	1.01	19.05	97.91	14.81	98.45	9.13	0.83
SRP	1084	34	11.43	97.61	23.53	94.47	4.77	0.91	19.05	97.28	11.76	98.44	7.00	0.83
Mi-2α	1107	11	11.43	99.72	72.73	94.59	41.37	0.89	4.76	99.09	9.09	98.20	5.25	0.96
Mi-2β	1097	21	7.14	98.53	23.81	94.27	4.85	0.94	9.52	98.28	9.52	98.28	5.52	0.92
Ku	1093	25	7.14	98.16	20.00	94.25	3.88	0.95	4.76	97.82	4.00	98.18	2.19	0.97

AB, antibody; IIM, idiopathic inflammatory myopathies; ILD, interstitial lung disease; LR, likelihood ratio; MAA, myositis-associated antibody; MSA, myositis-specific antibody; NPV, negative predictive value; PPV, positive predictive value.