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. 2020 Dec 10;20:1214. doi: 10.1186/s12885-020-07562-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Cytotoxicity within the GPC-1 expressing tumour cell population, mediated by MIL-38-CD3 BiTE. a. Fluorescently labelled DU-145 or Raji cells were incubated with MIL-38-CD3 BiTE or control BiTE CD3-PEG together with enriched T cells at a ratio of 10:1 T cell:tumour cell for 72 h. The proportion of dead cells was determined by topro-3-iodide uptake, by flow cytometry. b. Labelled PC3 cells were incubated with MIL-38-CD3 and T cells over 72 h and the proportion of dead cells was determined in the same way. ****p < 0.0001; ***p < 0.001, *p < 0.05