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. 2020 Dec 9;11:530. doi: 10.1186/s13287-020-02060-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Characterization of peripheral blood-derived hiPSCs. a Typical morphology of undifferentiated hiPSC colonies. The colonies grown over Matrigel have a homogeneous shape, smooth and regular edges, and positive staining for b OCT4, d NANOG, and c, e DAPI staining for the same colonies of b and d, respectively. Scale bar 200 μm. f Gene expression levels in samples collected before (erythroblasts) and after (hiPSCs) reprogramming, generated by referencing each gene to HMBS expression levels as an internal control. Healthy erythroblast mRNA was used as the comparative sample. *p value < 0.05 vs. erythroblast