Table 3.

Ratios of serious ADRs to total ADRs for the 20 most common culprit drugs classified by active ingredient

Culprit drugs	< 65 years	≥ 65 years	Odds ratio (95% CI)	P value
	Serious / Total ADRs (%)
Analgesics	41/2401 (1.7)	16/929 (1.7)	1.01 (0.56–1.81)	0.977
Tramadol	24/1606 (1.5)	10/727 (1.4)	0.92 (0.44–1.93)	0.824
Fentanyl	3/209 (1.4)	3/84 (3.6)	2.54 (0.50–12.86)	0.243
Nefopam	0/308 (0)	0/70 (0)	N/A	N/A
Acetaminophen	14/278 (5.0)	3/48 (6.3)	1.26 (0.35–4.55)	0.727
Contrast media	59/2744 (2.2)	34/775 (4.4)	2.09 (1.36–3.21)	0.001
Iohexol	4/848 (0.5)	9/247 (3.6)	7.98 (2.44–26.14)	< 0.001
Iopamidol	24/982 (2.4)	7/244 (2.9)	1.18 (0.50–2.77)	0.705
Iomeprol	7/420 (1.7)	6/93 (6.5)	4.07 (1.34–12.40)	0.008
Iopromide	16/220 (7.3)	4/83 (4.8)	0.65 (0.21–1.99)	0.443
Iodixanol	2/103 (1.9)	5/60 (8.3)	4.59 (0.86–24.45)	0.052
Ioversol	6/171 (3.5)	3/48 (6.3)	1.83 (0.44–7.62)	0.398
Anti-bacterial drugs	60/864 (6.9)	37/424 (8.7)	1.28 (0.84–1.96)	0.255
Ceftriaxone	16/324 (4.9)	13/104 (12.5)	2.75 (1.28–5.93)	0.008
Ciprofloxacin	8/174 (4.6)	5/84 (6.0)	1.31 (0.42–4.14)	0.641
Cefpiramide	1/152 (0.7)	1/72 (1.4)	2.13 (0.13–34.49)	0.587
Piperacillin	3/52 (5.8)	7/58 (12.1)	2.24 (0.55–9.17)	0.251
Vancomycin	10/131 (7.6)	7/56 (12.5)	1.73 (0.62–4.08)	0.289
Cefaclor	22/31 (71.0)	4/50 (8.0)	0.04 (0.01–0.13)	< 0.001
Anti-inflammatory and anti-rheumatic drugs	172/2009 (8.6)	39/232 (16.8)	2.16 (1.48–3.15)	< 0.001
Acetic acid	40/507 (7.9)	10/83 (12.0)	1.60 (0.77–3.34)	0.207
Acetylsalicylic acid	90/749 (12.0)	19/82 (23.2)	2.21 (1.26–3.86)	0.005
Propionic acid	42/753 (5.6)	10/67 (14.9)	2.97 (1.42–6.23)	0.003
Drugs for acid-related disorders
Ranitidine	15/251 (6.0)	5/88 (5.7)	0.95 (0.33–2.69)	0.920

Values represent numbers of cases with percentages in parentheses. P values were obtained from the chi-square test

ADR Adverse drug reaction, CI Confidence interval, N/A Not applicable