Table 2.
AUC0–12 change from day 1
| Parameter | BDP/F/G | BDP/F | BDP/F/G – BDP/F | |
|---|---|---|---|---|
| Mean difference | p value | |||
| FVC (mls) |
545 (414, 676) |
339 (208, 470) |
206 (54, 359) |
0.0116 |
| FEF25–75% (L/s) |
0.110 (0.077, 0.143) |
0.083 (0.050, 0.117) |
0.026 (0.001, 0.051) |
0.0395 |
| sGaw (L/s/kPa/L) |
0.311 (0.242, 0.381) |
0.213 (0.143, 0.282) |
0.099 (0.031, 0.167) |
0.0101 |
| Raw (kPa/L/s) |
− 0.279 (− 0.323, − 0.236) |
− 0.222 (− 0.266, − 0.179) |
− 0.057 (− 0.077, − 0.037) |
< 0.0001 |
| IC (mls) |
257 (135, 379) |
260 (138, 382) |
3 (− 146, 139) |
0.96 |
| FRC (mls) |
− 490 (− 632, − 348) |
− 387 (− 529, − 245) |
− 103 (− 217, 11) |
0.07 |
| TLC (mls) |
− 218 (− 319, − 117) |
− 137 (− 238, − 36) |
− 81 (− 196, 34) |
0.16 |
| R5–R20 (kPa/L/s) |
− 0.163 (− 0.195, − 0.131) |
− 0.118 (− 0.150, − 0.086) |
− 0.045 (− 0.065, − 0.025) |
0.0002 |
| X5 (kPa/L/s) |
0.203 (0.155, 0.252) |
0.156 (0.108, 0.205) |
0.047 (0.025, 0.069) |
0.0003 |
| ∆X5 (kPa/L/s) |
− 0.137 (− 0.219, − 0.056) |
− 0.095 (− 0.177, − 0.014) |
− 0.042 (− 0.086, 0.002) |
0.06 |
| Fres (1/s) |
− 7.201 (− 9.091, − 5.310) |
− 5.005 (− 6.896, − 3.115) |
− 2.195 (− 3.451, − 0.940) |
0.0016 |
| AX (kPa/L) |
− 2.911 (− 3.467, − 2.356) |
− 2.205 (− 2.761, − 1.650), |
− 0.706 (− 1.047, − 0.365) |
0.0004 |
Data = mean (95% CI) change in day 5 AUC0–12 from day 1. Treatment difference = BDP/F/G (AUC0–12 change at day 5 from day 1) – BDP/F (AUC0–12 change at day 5 from day 1)