Table 7.
Expression levels of transcription factors, microglial markers, inflammation cytokines, and CSF1R in the BA8
Genes | Con | SZ | Fold-change | P value§ | FDR q value | ||||
---|---|---|---|---|---|---|---|---|---|
Mean | SD | n | Mean | SD | n | (SZ/Con) | |||
KLF6 | 1.079 | 0.309 | 90 | 1.053 | 0.286 | 91 | 0.976 | 0.5209 | 0.7520 |
KLF4 | 0.846 | 0.616 | 87 | 0.978 | 0.875 | 92 | 1.156 | 0.4466 | 0.7369 |
TFAP2A | 0.954 | 0.576 | 88 | 0.949 | 0.535 | 90 | 0.995 | 0.9093 | 0.8832 |
MZF1 | 0.973 | 0.149 | 89 | 1.039 | 0.223 | 91 | 1.067 | 0.0421* | 0.1620 |
ZBTB14 | 1.006 | 0.130 | 87 | 0.997 | 0.159 | 89 | 0.991 | 0.5957 | 0.7644 |
IKZF1 | 1.115 | 0.485 | 89 | 1.013 | 0.521 | 91 | 0.909 | 0.0813 | 0.1878 |
NFATC2 | 0.969 | 0.313 | 89 | 1.042 | 0.485 | 91 | 1.076 | 0.8211 | 0.8832 |
AIF1 | 1.112 | 0.437 | 87 | 0.885 | 0.480 | 92 | 0.795 | 0.0009*** | 0.0100† |
CD68 | 1.020 | 0.412 | 87 | 0.920 | 0.472 | 91 | 0.902 | 0.0632 | 0.1824 |
IL1B | 0.760 | 0.954 | 89 | 0.675 | 1.320 | 91 | 0.888 | 0.0105* | 0.0604‡ |
TGFB1 | 1.007 | 0.315 | 88 | 1.078 | 0.493 | 92 | 1.071 | 0.9176 | 0.8832 |
CSF1R | 0.862 | 0.368 | 87 | 0.826 | 0.427 | 90 | 0.958 | 0.3978 | 0.7369 |
Values were normalized to GAPDH.
* P < 0.05, ***P < 0.001, ****P < 0.0001, †q < 0.05, ‡q < 0.1, §Mann–Whitney U test.