Figure 5.

(A) T-score maps of brain areas for which smaller volume was associated with greater subjective experience of negative non-target emotions after adjusting for diagnosis (six dummy variables accounting for patient groups), disease severity (CDR-Box), scanner type, and total intracranial volume. Results shown with and without adjusting for semantic knowledge (PPVT). Whole brain VBM analyses revealed that greater experience of negative non-target emotions was associated with smaller volume in left hemisphere regions, including caudate, putamen, and dorsal anterior insula (P_FWE < 0.05). (B) T-score maps of brain areas for which left-worse-than-right atrophy was associated with greater subjective experience of negative non-target emotions after adjusting for diagnosis (six dummy variables accounting for patient groups), disease severity (CDR-Box), scanner type, total intracranial volume, and semantic knowledge (PPVT). No clusters survived FWE correction. At a less stringent threshold, greater experience of negative non-target emotions was associated with left-worse-than-right atrophy in the caudate and parahippocampal gyrus (P_FWE < 0.09).