Figure 2.

The mechanism of action of CAAR-T cells and CAR-Treg cells against autoimmune disease. (A): MOG CAR-Treg cells effectively bind and is localized to the MOG⁺ oligodendrocytes in CNS and exert their immunosuppressive manner to protect myelin against immune attack. (B): (a); T cell expressing CAAR specific for B cell receptors targets aberrant B cells. (b); further, it inhibits B cell development from secreting autoreactive antibodies and prevents B cells from presenting autoantigens to autoreactive T cells, which leads to suppression of T cell-mediated autoimmune diseases.