Table 3.

Pearson correlations for FA and RD in significant tracts and verbal IQ in 22q11DS with and without prodromal symptoms.

			22q11DS−PS (n = 30)			22q11DS+PS (n = 21)
Sub-circuit	Tract	dMRI indices	r	p-Value	FDR	r	p-Value	FDR
Left DLPFC sub-circuit	Thalamus-rMFG	FA	0.298	n.s.	n.s.	–	–	–
	Striatum-rMFG	FA	0.219	n.s.	n.s.	−0.242	0.391	n.s.
	Striatum-rMFG	RD	−0.284	n.s.	n.s.	0.240	0.323	n.s.
Left VLPFC sub-circuit	Thalamus-IFG	FA	0.330	n.s.	n.s.	−0.391	0.080	n.s.
	Striatum-IFG	FA	–	–	–	−0.353	0.151	n.s.
	Thalamus-IFG	RD	−0.366	n.s.	n.s.	0.398	0.074	n.s.
	Striatum-IFG	RD	–	–	–	0.403	0.097	n.s.
Right DLPFC sub-circuit	Thalamus-rMFG	FA	0.296	n.s.	n.s.	–	–	–
	Striatum-rMFG	FA	0.690	n.s.	n.s.	−0.241	0.293	n.s.
	Striatum-rMFG	RD	−0.114	n.s.	n.s.	0.149	0.520	n.s.
Right VLPFC sub-circuit	Thalamus-IFG	FA	−0.193	n.s.	n.s.	−0.491	0.024	0.048
	Striatum-IFG	FA	–	–	–	−0.250	0.301	n.s.
	Thalamus-IFG	RD	0.129	n.s.	n.s.	0.487	0.025	0.050
	Striatum-IFG	RD	–	–	–	0.151	0.537	n.s.

Note: Pearson correlation coefficients r are given. Numbers of participants range from 51 to 45. 22q11DS−PS = individuals with 22q11DS without prodromal symptoms. 22q11DS+PS = individuals with 22q11DS with prodromal symptoms. L = left. R = right. FA = fractional anisotropy. RD = Radial Diffusivity. FDR = false discovery rate-adjusted p. The connections between thalamus-rMFG and striatum-rMFG represent the DLFPC sub-circuit of the fronto-striatal circuit, whereas thalamus-IFG and striatum-IFG represent the VLPFC sub-circuit. Results of p ≤ 0.05 are given in bold.

FDR was used to correct for multiple comparisons per sub-circuit (i.e., the DLPFC- and VLPFC-loops) and dMRI indices separately. Accordingly, the correction for multiple comparisons was made for two tracts within each sub-circuit.