Fig. 2.
Amino acid sequence alignment of the four human EYA proteins using CLUSTAL Omega (Sievers et al. 2011). The transactivation domain (blue box), putative Threonine phosphatase domain (green shaded box) and the tyrosine phosphatase (PTP) domain (red box) are indicated. The degree of conservation is shown below the amino acid sequences. An asterisk (*) indicates a fully conserved residue, a colon (:) indicates conservation between groups of strongly similar properties, and a period (.) indicates a group exhibiting weak similarity. A color version of this figure is available online.