Table 1.
Categories of patient-specific iPSC-CMs as disease models.
| Disease Model Categories | Related Genes | Reference | |||
|---|---|---|---|---|---|
| Inherited cardiomyopathy | Ion Channelopathy | Long QT syndrome (LQTS) | Type 1 | KCNQ1 | [23,24,25] |
| Type 2 | KCNH2 | [27,28] | |||
| Type 3 | SCN5A | [29,30] | |||
| Catecholaminergic polymorphic ventricular tachycardia (CPVT) | RYR2 | [34] | |||
| Structural Cardiomyopathy | Hypertrophic cardiomyopathy (HCM) | MYH7, MYBPC3, ACTC, TNNT2, MYL2, TNNI3 | [43,45,47] | ||
| Dilated cardiomyopathy (DCM) | TTN, TNNT2, SCN5A, DES, PLN, BAG3 | [51,52,53] | |||
| Arrhythmogenic cardiomyopathy (ACM) | DSP, DSC, DSG2 JUP, PKP2 | [54,56] | |||
| Duchenne muscular dystrophy (DMD) | DMD | [60] | |||
| Metabolic cardiomyopathy | Pompe disease (PD) | GAA | [64,65,66] | ||
| Barth syndrome (BTHS) | TAZ | [70] | |||
| Chronic nonhereditary cardiomyopaty | Chronic Heart Failure | Heart failure with reduced ejection fraction (HFrEF) | N/A | [74] | |