Table 3.
Minimum inhibitory concentration (MIC) of the pure histidine derivative and its HM catanionic mixtures. Values in brackets correspond to the concentration of DMHNHC14 in the catanionic formulations at their MIC values (MICH). The MIC values of sodium myristate were higher than 113 μM for all microorganisms tested.
| MIC (μM) | ||||||
|---|---|---|---|---|---|---|
| DMHNHC14 | 80:20 HM | 60:40 HM | 50:50 HM | 40:60 HM | 20:80 HM | |
|
Kocuria rhizophila ATCC 9341 |
28 | 28 (22) |
56 (34) |
56 (28) |
56 (22) |
227 (45) |
|
Bacillus subtilis ATCC 6633 |
28 | 28 (22) |
56 (34) |
56 (28) |
113 (45) |
454 (90) |
|
Staphylococcus epidermidis ATCC 12228 |
14 | 56 (45) |
56 (34) |
28 (14) |
113 (45) |
227 (45) |
|
Staphylococcus aureus ATCC 29213 |
28 | 28 (22) |
28 (17) |
28 (14) |
56 (45) |
227 (45) |
|
Klebsiella pneumoniae ATCC 13883 |
113 | 227 (181) |
227 (136) |
> (>227) |
> (>181) |
> (>90) |
|
Escherichia coli ATCC 25922 |
113 | 113 (90) |
227 (136) |
>454 (>227) |
>454 (>181) |
>454 (>90) |
|
Pseudomonas aeruginosa ATCC 27853 |
227 | >454 (>363) |
>454 (>271) |
>454 (>227) |
>454 (>181) |
>454 (>90) |
|
Candida albicans ATCC 10231 |
28 | 28 (22) |
56 (34) |
56 (28) |
56 (22) |
113 (23) |