Table 3.

Overview of the most frequently used reprogramming factors for iPSC derivation. Revised by [44,55].

Reprogramming Factors	Main Function or Effect	References
c-Myc	Maintaining the capacity of pluripotency and self-regulation	[11]
E-cadherin	Suppressor, replacement of Oct4	[56]
Glis1	Increased pluripotency, effect on Wnt/β-catenin pathways; PI3K; TGF	[57]
Klf4	Maintaining pluripotency and self-regulation	[11]
Lin28	maintenance of pluripotency, translational enhancer, Let7 inhibitor	[58]
Nanog	Maintaining pluripotency and self-regulation	[58]
Oct4	Maintaining pluripotency and self-regulation	[11,59]
Sox2	Maintaining pluripotency and self-regulation	[11,60]

(Glis1—Glis Family Zinc Finger 1, Lin28—Protein Lin-28 Homolog A, PI3K—Phosphoinositide 3-Kinase, TGF—Transforming Growth Factor).