Table 6.

Summary of the most common advantages and disadvantages of 3D cultivation [96,105].

3D Models
Pros	Cons
Modeling of difficult to access tissues	Many non-uniform protocols
Monitoring developmental stages	Many different materials
Diversity of cell types	Great variability of results
Interaction between cell types	Insufficient vascularization
Identical genetic background	Interaction
Possibility of genetic manipulation
Easy handling
Spatial organization
Tailor-made microenvironment