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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Hypertension. 2020 Sep 28;76(5):1461–1469. doi: 10.1161/HYPERTENSIONAHA.120.15928

Figure 2. Impact of high dietary sodium intake on NCC regulation in Dahl rats.

Figure 2.

(A) total WNK1 and WNK4 expression and respective immunoblots, (B) total SPAK and OxSR1 expression, and respective immunoblots and, (C) total pSPAK (S373)/pOxSR1 (S325) expression and pSPAK (T233)/pOxSR1 (T185) expression and respective immunoblots in 3-month old male Dahl Salt-Resistant (DSR) and Dahl Salt-Sensitive (DSS) rats fed a 21-day normal salt (NS; 0.6% NaCl) or high salt (HS, 4% NaCl) diet. N=5/6 per group mean ± SD. Protein expression is shown as fold change with NS target protein expression set to 1 for each group. Differences in NS and HS target protein expression within each treatment group were determined using a student’s t test. *P < 0.05 vs. respective NS group.