Table 1:

CLAD Onset Cohort Clinical Characteristics & CLAD Phenotypes¹

	Obstruction2	Restriction3	CT Opacities4	n (%)
BOS	+	−	−	52 (67.5%)
RAS	−	+	+	18 (23.4%)
Mixed	+	+	+	3 (3.9%)
U-CLAD	+	−	+	4 (5.2%)

Definition of abbreviations: CLAD = chronic lung allograft dysfunction, CT = computed tomography scan, BOS = bronchiolitis obliterans syndrome, RAS = restrictive allograft syndrome, U-CLAD = undefined CLAD phenotype

¹Assessed during CLAD onset period (i.e. first 3 months after CLAD onset)

²Defined as FEV₁/FVC ratio of ≤70%; for single lung transplant recipients obstruction was defined as a decline in FEV₁/FVC ratio relative to the ratio of their baseline FEV₁ and FVC values.

³Defined as TLC ≤90% post-transplant baseline; when TLC information was not available, decline in FVC ≤80% of post-transplant baseline was used.

⁴CT scan opacities were defined as ground glass, consolidation, reticulation, septal and/or pleural thickening not due to airways disease.