Table 1.
Surgery | Group | Total Number | Neurological Scores | ||
---|---|---|---|---|---|
1 Day | 10 Days | 31 Day | |||
Sham-operated | AAV-pDCX-FerrH | 3 | 0 | 0 | 0 |
Sham-operated | AAV-pDCX-eGFP | 3 | 0 | 0 | 0 |
Sham-operated | PBS | 3 | 0 | 0 | 0 |
MCAO | AAV-pDCX-FerrH | 3 | 3 (1–4) | 2 (0–3) | 2 (0–3) |
MCAO | AAV-pDCX-eGFP | 3 | 3 (2–4) | 2 (1–3) | 2 (2–3) |
MCAO | PBS | 3 | 3 (3–4) | 3 (2–4) | 2 (2–3) |
1 Neurological scores are presented as median (range). A score of 0 represents no dysfunction of the central nervous system; a score of 1 represents mild neurological deficit; a score of 2, moderate deficit; and a score of 3, severe deficit [30,31]. Abbreviations: MCAO, middle-cerebral-artery occlusion; PBS, phosphate-buffered saline; AAV, adeno-associated viral backbone; pDCX, doublecortin promoter; FerrH, ferritin heavy chain; eGFP, enhanced green fluorescent protein.