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Changes over time of (a) tidal volume (VT); (b) frequency of breathing (F), (c) minute ventilation (VE), (d) heart rate (HR) and (e) mean arterial blood pressure (MAP) after iv injection of various doses of NPFF. Significant drop in VE is produced by the highest dose of NPFF. Short-lived increase in MAP is evoked mostly by the two highest doses of NPFF. The data are presented as median ± QD; * p < 0.05 vs. baseline value; n = 5–6 per dose.
