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Overview of Tau immunotherapies in clinical trial. Indicated are passive and active Tau immunotherapy agents that have reached clinical trials Phase 1/2, for binding both intra and extracellular Tau in the CNS. The Roche RG7345 antibody has since been discontinued (Clinicaltrials.gov). Key: conform. -dep. refers to conformation-dependent antibody recognition of Tau, 16x means 16 Tau fragments repeats, and eTau refers to extracellular Tau.
