Table 1.
Clinicopathological characteristics of male breast lymphoma cases
|
No. |
Age [years] |
Size of tumor [cm] |
Site of tumor |
Clinical information |
Lymph nodes |
Histology |
Primary / secondary |
Author(s), year [Ref. No.] |
|
1. |
9 |
N/A |
N/A |
N/A |
N/A |
N/A |
Primary |
Docimo, 1959 [14] |
|
2. |
35 |
N/A |
R breast |
N/A |
N/A |
N/A |
Primary |
Sinner, 1961 [14] |
|
3. |
38 |
N/A |
R breast |
N/A |
N/A |
N/A |
Primary |
Bettini & Saint Omer, 1964 [14] |
|
4. |
81 |
4×4 |
R breast |
N/A |
Present |
B-cell, DSNC |
Primary |
Aoi et al., 1985 [14] |
|
5. |
65 |
4×5×2 |
L breast |
N/A |
Absent |
B-cell, DLBCL |
Primary |
Yamamoto et al., 1986 [14] |
|
6. |
74 |
>2 |
R breast |
N/A, prostatectomy |
Present |
B-cell, DLBCL |
Primary |
Kawanisi et al., 1989 [14] |
|
7. |
81 |
N/A |
Bilateral, diffuse |
Gynecomastia, suspicious of prostatic nodule, Estrogen TX (9 years) |
Present |
B-cell, DLBCL |
Primary |
Hugh et al., 1990 [15] |
|
8. |
65 |
7×5x5 |
L breast |
N/A |
Absent |
B-cell, DLBCL |
Primary |
Kitaoka et al., 1900 [14] |
|
9. |
45 |
5.6×5×3.5 / 4×3.5×2.2 |
Bilateral, under nipple |
N/A |
Absent |
B-cell, DLBCL |
Primary |
Murakami et al., 1993 [14] |
|
10. |
69 |
11×11×8 |
R breast |
N/A, Estrogen TX (10 years) |
Absent |
B-cell, DM |
Primary |
Okada et al., 1995 [14] |
|
11. |
N/A |
N/A |
N/A |
N/A |
N/A |
DLBCL |
Primary |
Abbondanzo et al., 1996 [16] |
|
12. |
N/A |
N/A |
N/A |
N/A |
N/A |
DLBCL |
Primary |
Abbondanzo et al., 1996 [16] |
|
13. |
76 |
5.6×5.5×3.5 |
R breast |
Gynecomastia |
Absent |
B-cell, DLBCL |
Primary |
Murata et al., 1996 [17] |
|
14. |
65 |
4×5×2.5 |
L breast |
Elastic-hard mass |
Present |
B-cell, DLBCL |
Primary |
Hinoshita et al., 1998 [18] |
|
15. |
69 |
2.4×3.9 |
L breast |
Palpable mass, bilateral gynecomastia |
Absent |
B-cell, DLBCL |
Primary |
Sashiyama et al., 1999 [14] |
|
16. |
N/A |
N/A |
N/A |
N/A |
N/A |
N/A |
N/A |
Wong et al., 2002 [19] |
|
17. |
44 |
2 |
L breast |
Palpable mass |
Present |
B-cell, DLBCL |
Primary |
Cabras et al., 2004 [20] |
|
18. |
67 |
6×5×4 |
R breast |
Palpable mass |
Present |
B-cell, DLBCL |
Primary |
Mpallas et al., 2004 [21] |
|
19. |
50 |
4×4×7 |
R breast |
Palpable breast mass, axillary masses |
Present |
B-cell, DLBCL (ARL) |
Primary |
Chanan-Khan et al., 2005 [22] |
|
20. |
63 |
N/A |
R breast |
Palpable mass |
Present |
DLBCL |
Secondary |
Vignot et al., 2005 [23] |
|
21. |
33 |
N/A |
L breast |
Breast mass |
N/A |
TCRBCL |
Secondary |
Duncan et al., 2006 [2] |
|
22. |
65 |
3 |
R breast |
Palpable mass |
Absent |
T-cell, ALCL |
Primary |
Gualco et al., 2009 [24] |
|
23. |
64 |
6×7 |
L breast |
Painless growing lump |
Absent |
B-cell, DLBCL |
Primary |
Miura et al., 2009 [25] |
|
24. |
62 |
7×4 |
L breast |
Palpable breast mass |
Present |
B-cell, MZL |
Primary |
Duman et al., 2011 [26] |
|
25. |
51 |
2.3 |
L breast |
Palpable mass |
Absent |
T-cell, ALCL |
Primary |
Ko et al., 2012 [27] |
|
26. |
76 |
N/A |
L breast |
Palpable lumps |
Absent |
B-cell, DLBCL |
Primary |
Mouna et al., 2012 [28] |
|
27. |
48 |
4.8×4.7 |
R breast |
Painful lump, HIV-positive, ART-induced gynecomastia |
Present |
B-cell, DLBCL |
Primary |
Rastogi et al., 2012 [29] |
|
28. |
85 |
N/A |
R breast |
Palpable mass |
N/A |
B-cell lymphoma |
N/A |
Surov et al., 2012 [8] |
|
29. |
46 |
3×4 |
R breast |
Palpable mass |
Present |
DLBCL |
Primary |
Lokesh et al., 2013 [30] |
|
30. |
60 |
5×4 |
L breast |
Palpable mass |
Present |
SLL |
Primary |
Lokesh et al., 2013 [30] |
|
31. |
50 |
2×2 |
L breast |
Gynecomastia, palpable lump behind nipple |
Present |
B-cell, DLBCL |
Primary |
Mukhtar et al., 2013 [31] |
|
32. |
70 |
N/A |
R breast |
Bilateral enlargement, R breast induration |
Absent |
B-cell recurrence of MCL |
Secondary |
Ikeda et al., 2015 [3] |
|
33. |
56 |
4×2.5×3.7 |
R breast |
Palpable mass |
Present |
B-cell, MCL |
Secondary |
Ruiz Pardo et al., 2017 [32] |
|
34. |
N/A |
N/A |
N/A |
N/A |
|
B-cell, aggressive |
Primary |
Franco Pérez, 2017 [33] |
|
35. |
65 |
1.7×1.5 |
R breast |
Cervical lymphadenopathy, gynecomastia |
Present |
B-cell, DLBCL |
Secondary |
Sharma, 2017 [34] |
|
36. |
74 |
N/A |
R breast |
N/A |
N/A |
B-cell, DLBCL |
Primary |
Tokuyama et al., 2017 [35] |
|
37. |
47 |
N/A |
Bilateral |
Gynecomastia |
Present |
HL |
Secondary |
Lin & Dalal, 2018 [1] |
|
38. |
78 |
2.5×2 |
R breast |
Breast mass |
Absent |
CLL |
Secondary |
Present case |
N/A: Not available; R: Right; L: Left; HIV: Human immunodeficiency virus; ART: Antiretroviral treatment; DSNC: Diffuse small non-cleaved cell; DLBCL: Diffuse large B-cell lymphoma; DM: Diabetes mellitus; ARL: Acquired immunodeficiency syndrome (AIDS)-related lymphoma; TCRBCL: T-cell/histiocyte-rich B-cell lymphoma; ALCL: Anaplastic large-cell lymphoma; MZL: Marginal zone lymphoma; SLL: Small lymphocytic lymphoma; MCL: Mantle cell lymphoma; HL: Hodgkin’s lymphoma; CLL: Chronic lymphocytic leukemia.