Table III.
Gene Expression Changes in Lung Macrophages With P. aeruginosa EV-Treatment vs LPS Only*
| Gene | Normalized Read Counts | |||
|---|---|---|---|---|
| P. aeruginosa EVs | LPS Only | |||
| Untreated | EV-treated | Untreated | LPS-treated | |
| CCL3 | 362 | 10822 | 262 | 11336 |
| CCL3L1 | 436 | 13778 | 238 | 15346 |
| CCL4 | 183 | 4136 | 81 | 4608 |
| CCL18 | 14051 | 5355 | 6762 | 3409 |
| CD14 | 788 | 7891 | 720 | 6187 |
| CD44 | 2426 | 5581 | 3444 | 5774 |
| CD74 | 8574 | 1947 | 6127 | 1240 |
| CD81 | 6882 | 3512 | 6359 | 3368 |
| CTSS | 7537 | 3974 | 6103 | 3260 |
| CXCL2 | 146 | 5345 | 60 | 3764 |
| CXCL3 | 291 | 16090 | 74 | 13847 |
| CXCL5 | 1765 | 40784 | 708 | 39122 |
| HLA-A | 4564 | 2287 | 3204 | 2086 |
| HLA-B | 4015 | 2351 | 4153 | 2823 |
| HLA-DRA | 15646 | 3758 | 11216 | 2430 |
| HLA-DRB3 | 5002 | 1413 | 3820 | 925 |
| IL1β | 370 | 27129 | 176 | 22714 |
| IL1RN | 229 | 1086 | 463 | 2502 |
| IL8 | 1502 | 102843 | 766 | 67858 |
| LAMP1 | 2631 | 1727 | 3707 | 2095 |
| LGALS3 | 5035 | 1840 | 4480 | 1890 |
| MARCO | 1912 | 652 | 880 | 152 |
| MRC1 | 1046 | 1652 | 669 | 2276 |
| S100A8 | 407 | 2492 | 342 | 2638 |
| SH2D1B | 765 | 18478 | 347 | 17515 |
*
P. aeruginosa-derived LPS (1000ng/ml) 48 Hours
n=2