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. 2020 Nov 30;16(11):e1008085. doi: 10.1371/journal.pcbi.1008085

Fig 3. Additional information contained in pairwise covariation in RNA MSAs.

Fig 3

For each of the 127 Rfam 14.1 seed MSAs with more than 100 sequences [36], we infer a predicted consensus structure (including nested and non-nested base pairs) using CaCoFold and R-scape [41, 42]. (A) Primary information content (X axis) versus the sum of primary and secondary information content (Y axis). (B) Sum of primary and secondary information content (X axis) versus the information content from all three levels of structure (Y axis) (C) Secondary information content (X axis) versus the sum of information content from secondary and tertiary structure (Y axis). Not included in (C) is ROOL (RF03087), with 305.3 bits of primary information, 174.5 bits of secondary information, and 10.7 bits of tertiary information.