Table 5. Effect of D614G mutation on the generation of SARS-CoV-2 S protein specific CD8 T cell epitopes by different HLA alleles.

Alleles	Epitopes gained		Epitopes lost		Affinity decreased		Affinity increased
	Pos	Sequence	Pos	Sequence	Pos	Sequence	Pos	Sequence
HLA-A*0101		None	612	YQDVNCTEV		None		None
HLA-A*0201		None		None		None	612	YQGVNCTEV
HLA-A*0203	612	YQGVNCTEV		None		None		None
HLA-A*0205	607	QVAVLYQGV		None		None		None
	612	YQGVNCTEV
HLA-A*0206	607	QVAVLYQGV		None		None	612	YQGVNCTEV
	614	GVNCTEVPV
HLA-A*0207		None	612	YQDVNCTEV		None		None
HLA-A*0211		None		None	610	VLYQGVNCT	612	YQGVNCTEV
					614	GVNCTEVPV
HLA-A*0212		None		None	610	VLYQGVNCT	612	YQGVNCTEV
					614	GVNCTEVPV
HLA-A*0216		None		None	610	VLYQGVNCT	612	YQGVNCTEV
					614	GVNCTEVPV
HLA-A*0219		None		None	610	VLYQGVNCT		None
					612	YQGVNCTEV
					614	GVNCTEVPV
HLA-A*0250		None		None	607	QVAVLYQGV		None
					610	VLYQGVNCT
					612	YQGVNCTEV
HLA-A*2403	611	LYQGVNCTE		None		None		None
HLA-A*2501	607	QVAVLYQGV		None		None		None
HLA-A*2601	607	QVAVLYQGV		None		None		None
HLA-A*2603		None		None		None		None
HLA-A*6601		None		None	612	YQGVNCTEV		None
HLA-A*6802		None	614	DVNCTEVPV	607	QVAVLYQGV		None
HLA-A*6901		None	614	DVNCTEVPV	607	QVAVLYQGV		None
HLA-B*1509		None	612	YQDVNCTEV		None		None
HLA-B*2720		None		None	612	YQGVNCTEV		None
HLA-B*3901		None	612	YQDVNCTEV		None		None
HLA-B*4801		None		None		None	606	NQVAVLYQG
HLA-C*0501		None	612	YQDVNCTEV		None		None
HLA-C*0602		None		None		None	612	YQGVNCTEV
HLA-C*0802		None	612	YQDVNCTEV		None		None
HLA-C*1203	610	VLYQGVNCT	612	YQDVNCTEV		None		None
HLA-C*1402		None		None	611	LYQGVNCTE		None