Fig 3. Summary of findings (GRADE assessment).

Notes= 1) Evidence downgraded one level due to risk of bias issues: multiple unclear risk related to patient selection and index test, several studies at high risk of bias in flow and timing Domain; 2) Evidence downgraded one level due to indirectness: unclear or high concerns about applicability of selected populations enrolled in studies; 3) Evidence downgraded one level due to inconsistency: tausquare =1.39.