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. 2020 Dec 3;9:e62618. doi: 10.7554/eLife.62618

Figure 6. Mechanisms underlying the preservation of motion-evoked DSGC inhibition by the SAC-SAC-DSGC disinhibitory motif.

Figure 6.

The inverted algorithm of the SAC-SAC-DSGC disinhibitory motif arises from three mechanistic components during motion processing in the noisy background. The SAC-SAC inhibition contributes to a strong RF surround of SACs (1), which enables motion-evoked suppression of SAC Vm that dampens SAC flicker response (2). Dampened SAC flicker response before its motion-evoked response prevents short-term synaptic depression of the SAC-DSGC synapse during motion stimuli (3) and preserves the strength of null-direction inhibition of the DSGC (see more in Discussion).