Appendix 1—figure 2. MRI-based manual tissue segmentation pipeline shown for a single participant.

Tissue properties were set as follows, with a medium alpha power (y) = 1.43. Panel (A) Skin and scalp (green). Alpha coefficient: 2.05 dB/(MHz ^y cm), sound speed: 1732 m/s, density: 1100 kg/m³. Panel (B) Bone (red). Alpha coefficient: 8.83 dB/(MHz ^y cm), sound speed: 2850 m/s, bulk density: 1732 kg/m³. Panel (C) Brain (blue). Alpha coefficient: 1.00 dB/(MHz ^y cm), sound speed: 1552 m/s, density: 1040 kg/m³. Panel (D) The three masks were used to set the properties of the acoustic propagation medium in the subsequent numerical simulation. The background medium was set as water (black) with the following properties: Alpha coefficient: 0.05 dB/(MHz y cm), sound speed: 1482 m/s, density: 1000 kg/m³.