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. 2020 Dec 2;9:e61487. doi: 10.7554/eLife.61487

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© 2020, Blanden et al

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Figure 8. — (A) H1299 cells were stably transfected with 1 of 12 p53 mutants or an empty vector and treated with ZMC1 for 4 hr. p53 conformation was probed by IF using PAB240, which binds selectively to unfolded p53. TOV112D (p53 R175H) and the parental cell line were used as unfolded and native conformation controls respectively. (B) p53 refolding of R175H and E285K with ZMC1 and different incubation temperatures. Sample size: 2; replicates: two independent experiments; outliers/exclusions: no.