Table 4.
Association of the ANGPTL8 rs2278426 (C/T) polymorphism genotypes with biochemical parameters in the pre-DM group.
| Variables | Genotype groups | All P values | Pairwise comparisons | ||||
|---|---|---|---|---|---|---|---|
| CC (n = 208) | CT (n = 202) | TT (n = 50) | P1 | P2 | P3 | ||
| Age (years) | 52.19 ± 12.75 | 54.82 ± 11.47 | 54.94 ± 9.70 | 0.06 | 0.077 | 0.428 | 1.000 |
| Male/female (n) | 94/114 | 89/113 | 17/33 | — | — | — | — |
| BMI (kg/m2) | 27.00 ± 3.76 | 27.36 ± 4.24 | 26.52 ± 3.78 | 0.362 | 1.000 | 1.000 | 0.548 |
| SBP (mm/Hg) | 125.94 ± 12.11 | 126.19 ± 11.93 | 125.80 ± 12.12 | 0.967 | 1.000 | 1.000 | 1.000 |
| DBP (mm/Hg) | 76.90 ± 8.57 | 76.17 ± 8.97 | 75.34 ± 8.31 | 0.46 | 1.000 | 0.771 | 1.000 |
| TC (mmol/L) | 4.93 ± 0.94 | 5.01 ± 0.96 | 4.72 ± 0.90 | 0.144 | 1.000 | 0.516 | 0.157 |
| TG (mmol/L) | 1.62 ± 1.05 | 1.67 ± 1.14 | 1.38 ± 0.75 | 0.213 | 1.000 | 0.426 | 0.237 |
| HDL (mmol/L) | 1.31 ± 0.24 | 1.29 ± 0.25 | 1.28 ± 0.24 | 0.692 | 1.000 | 1.000 | 1.000 |
| LDL (mmol/L) | 3.06 ± 0.77 | 3.08 ± 0.77 | 2.74 ± 0.72 | 0.017 | 1.000 | 0.024 | 0.018 |
| FPG (mmol/L) | 5.69 ± 0.62 | 5.73 ± 0.48 | 6.01 ± 0.71 | <0.001 | 1.000 | 0.001 | 0.008 |
| PBG (mmol/L) | 7.93 ± 1.32 | 8.39 ± 1.10 | 8.56 ± 1.79 | 0.002 | 0.001 | 0.006 | 1.000 |
| FINS (µU/mL) | 9.24 ± 3.20 | 8.59 ± 2.72 | 7.62 ± 3.81 | <0.001 | 0.095 | 0.003 | 0.142 |
| Postprandial insulin (µU/m) | 64.53 ± 23.46 | 64.70 ± 20.76 | 57.58 ± 22.96 | 0.109 | 1.000 | 0.144 | 0.131 |
| HbA1c (%) | 5.71 ± 0.36 | 5.79 ± 0.37 | 5.98 ± 0.57 | <0.001 | 0.139 | <0.001 | 0.007 |
| HOMA-IR | 2.34 ± 0.88 | 2.19 ± 0.73 | 2.05 ± 1.07 | 0.049 | 0.223 | 0.094 | 0.903 |
| HOMA-B | 92.50 ± 44.07 | 80.19 ± 31.02 | 65.25 ± 40.79 | <0.001 | 0.004 | <0.001 | 0.043 |
Values are shown as mean ± standard deviation. Each group was compared by one-way analysis of variance. P values were corrected by a post hoc Bonferroni test. Pre-DM: prediabetes; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; TG: triglycerides; HDL: high-density lipoprotein; LDL: low-density lipoprotein; FPG: fasting plasma glucose; PBG: postprandial blood glucose; FINS: fasting insulin; HbA1c: glycosylated hemoglobin; HOMA-IR/-B: homeostasis model assessment-insulin resistance/β-cell function. P1:CT vs. CC; P2:TT vs. CC; P3:TT vs. CT.