Table 2.

H₂S regulates insulin secretion and islet β cells apoptosis.

Action	Cells/Model	H2S gas/donor application (concentration)	Effects	Refs.
Insulin section
In vitro study	INS-1E cells	H2S gas (100 μM)	Inhibited	[22]
	HIT-T15 cells	NaHS (100 μM)	Inhibited	[17]
	MIN6 cells	NaHS (10, 100 and 1000 μM)	Inhibited	[19]
	Isolated mouse islets	NaHS (100 and 300 μM)	Inhibited	[24]
	Isolated mouse islets	NaHS (100 and 1000 μM)	Inhibited	[19]
In vivo study	Zucker diabetic fatty rats	–	Inhibited	[18]
	Nonfasting wild-type mice	NaHS (39 μmol/kg)	Inhibited	[26]
Islet β cell apoptosis
In vitro study	INS-1E cells	H2S gas (100 μM)	Promoted	[25]
	Isolated mouse islets	NaHS (100 μM)	Inhibited	[20]
	Isolated mouse islets	NaHS (100 μM)	Inhibited	[28]
	MIN6 cells	NaHS (100 μM)	Inhibited	[28]
In vivo study	Streptozotocin-induced diabetic mice	–	Promoted	[26]
	High fat diet-induced obese mice	–	Inhibited	[21]