Table 4.
H2S regulates glucose uptake, adipogenesis and lipolysis in adipocytes.
| Action | Cells/Model | H2S gas/donor application (concentration) | Effects | Refs. |
|---|---|---|---|---|
| Glucose uptake | ||||
| 3T3-L1 adipocytes | H2S gas (10, 25 and 50 μM) | Promoted | [45] | |
| 3T3-L1 adipocytes | Na2S (10 and 100 μM) | Promoted | [44] | |
| 3T3-L1 adipocytes | NaHS (25, 50 and 100 μM) | Promoted | [45] | |
| 3T3-L1 adipocytes | NaHS (100 μM) | Promoted | [43] | |
| 3T3-L1 adipocytes | NaHS (100, 500 and 1000 μM) | Inhibited | [48] | |
| Adipogenesis | ||||
| 3T3-L1 adipocytes | H2S gas (100 μM) | Promoted | [43] | |
| 3T3-L1 adipocytes | NaHS (30 μM) | Promoted | [50] | |
| 3T3-L1 adipocytes | NaHS (50 μM) | Promoted | [49] | |
| 3T3-L1 adipocytes | GYY4137 (50 μM) | Promoted | [49] | |
| 3T3-L1 adipocytes | GYY4137 (100 μM) | Promoted | [43] | |
| Lipolysis | ||||
| 3T3-L1 adipocytes | NaHS (50 μM) | Inhibited | [49] | |
| 3T3-L1 adipocytes | GYY4137 (50 μM) | Inhibited | [49] | |
| Primary rat adipocytes | GYY4137 (1000 μM) | Inhibited | [57] | |
| Adipokines or inflammatory factors secretion | ||||
| 3T3-L1 adipocytes | NaHS (50 μM) | Attenuated high glucose-induced decrease in adiponectin and the increase in MCP-1 section | [58] | |
| High fat diet-induced diabetic mice | SG-1002 (20 mg/kg/day) | Increased the plasma adiponectin level | [59] | |