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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Semin Liver Dis. 2020 Jun 11;40(4):346–357. doi: 10.1055/s-0040-1713115

Figure 2. Mixed lineage kinase 3 (MLK3) activation during hepatocyte sublethal lipotoxic injury:

Figure 2.

Lipotoxicity during nonalcoholic steatohepatis (NASH) activates MLK3 mainly via the small GTP-binding proteins Cdc42/Rac1, MLK3 activation triggers a downstream MAPK signaling cascade that promotes the release of C-X-C motif chemokine 10 (CXCL10)‐bearing extracellular vesicles (EV)s from hepatocytes by a mechanism that involves CXCL10 induction through a p38/ signal transducer and activator of transcription 1(STAT1)‐dependent mechanism, and CXCL10 trafficking into EVs through a JNK‐dependent mechanism.