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. 2020 Nov 27;11:593219. doi: 10.3389/fimmu.2020.593219

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Copyright © 2020 Hu, Xiao, Dong, Guo, Wu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The potential mechanism of CD47-SIRPα inhibition in GBM. Targeting the CD47-SIRPα axis may exert anti-GBM effects through the following four pathways: (A) Eliminate GBM cells through traditional antibody Fc-dependent mechanisms, including ADCP, ADCC, and CDC. (B) it leads to enhanced tumor cell phagocytosis by macrophage through disrupting the binding of CD47 to SIRPα. (C) Promote apoptosis of GBM cells. (D) Restore dendritic cells' function to present antigen to CD4+ and CD8+T cells, thereby stimulating an anti-tumor adaptive immune response.