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. 2020 Dec 10;10:21711. doi: 10.1038/s41598-020-78863-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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A heatmap representing fold changes in the housekeeping genes’ expressions throughout the iPS reprogramming process. The genes are grouped by fold-expression change into one of three groups, represented by dark blue, medium blue and light blue. Four time points during the reprogramming are indicated under the heatmaps, and the gene names are written on the left. The dark blue color represents no expression change, and Day 0 is taken as the “time point zero” before initiation of reprogramming. The medium blue color represents the expression change of more than statistically significant 1.5-fold, but less than threefold. Light blue represents gene expression change greater than threefold, compared to time point zero (Day 0).